VRayDenoiser offers a choice between the default V-Ray denoiser, the the NVIDIA AI denoiser and the Intel Open Image denoiser (V-Ray's implementation of the Intel® Open Image Denoise).. Each offers a different denoising algorithm that comes with different benefits.
V-Ray – V-Ray's denoising algorithm. It can utilize the CPU or the GPU (AMD or NVIDIA GPUs) to perform the denoising. It is consistent when denoising render elements, as it applies the same denoising operator to all render channels. This means that it is recommended for denoising the render elements to be used for compositing back the beauty image. In addition, it comes with a Denoiser Tool, which is recommended for denoising animation by using frame blending.
NVIDIA AI – V-Ray's integration of NVIDIA's AI-based denoising algorithm. The NVIDIA AI denoiser requires an NVIDIA GPU to work, regardless of whether the actual rendering was performed on the CPU or GPU. This means that rendering on the CPU will still require an NVIDIA GPU for denoising with the NVIDIA AI denoiser and has some advantages and drawbacks compared to the Default V-Ray Denoiser. For example, the NVIDIA AI denoiser performs the denoising faster, but is not consistent when denoising render elements. This means that there will be differences between the original RGB image and the one reconstructed from render elements that are denoised with the NVIDIA AI denoiser. It also doesn't support cross-frame denoising and will likely produce flickering when used in animation.
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The Nvidia AI denoiser only works on Nvidia Maxwell and newer GPU architectures.
Intel Open Image – V-Ray's integration of Intel Open Image Denoise. The Intel Open Image denoiser works with your CPU device and does not use hardware acceleration. This denoiser mode Like NVIDIA AI, the Intel Open Image denoiser is best used suited for interactive renderingwith a CPU configuration.
These options reside in the V-Ray Asset Editor > Settings > Render.