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The V-Ray installation includes a standalone denoising tool called vdenoise that can be used to denoise still images or animations outside of Cinema 4D. This is especially useful for animations because the standalone tool can look at multiple frames at once and produce a better denoising result. The vdenoise tool works with either .vrimg or multichannel OpenEXR files and writes out files with the same format.
Note that there is no GUI version of the Denoiser tool for macOS.
Installation
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The vdenoise tool is a part of the V-Ray for Cinema 4D installation. You can quickly open a command prompt in the folder where the vdenoise tool is located, or run the executable to bring out vdenoise's GUI.
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