For information on render region and saving .exr files with render region, see the V-Ray Frame Buffer page.
If rendering with V-Ray Standalone, use the -deleteResumableFileOnSuccess=1 command to automatically delete the resumable file if the frame is completed successfully. This applies to additional .vrimg or .vrprog files, and not when the output image file is .vrimg. The default command value is 0, which keeps the resumable file.